Disuse rescues the age-impaired adaptive response to external loading in mice
نویسندگان
چکیده
منابع مشابه
Prolonging disuse in aged mice amplifies cortical but not trabecular bones’ response to mechanical loading
OBJECTIVE Short-term neurectomy-induced disuse (SN) has been shown to restore load responses in aged mice. We examined whether this restoration was further enhanced in both cortical and trabecular bone by simply extending the SN. METHODS Following load:strain calibration, tibiae in female C57BL/J6 mice at 8, 14 and 20 weeks and 18 months (n=8/group) were loaded and bone changes measured. Effe...
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متن کاملAging alters the skeletal response to disuse in the rat.
Disuse has been shown to cause a rapid and dramatic loss of skeletal mass and strength in the load-bearing bones of young and mature animals and humans. However, little is known about the skeletal effects of disuse in aged mammals. The present study was designed to determine whether the skeletal effects of disuse are maintained with extreme age. Fischer 344/Brown Norway male rats (6 and 32 mo o...
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ژورنال
عنوان ژورنال: Osteoporosis International
سال: 2015
ISSN: 0937-941X,1433-2965
DOI: 10.1007/s00198-015-3142-x